Women health


What is the Sickle Cell Disease Trait?

Sickle cell trait (AS) is not a sickle cell disease type. It's an inherited disorder in which red blood cells synthesize both hemoglobin A and S, but always more A than S. Sickle cell trait carriers are generally healthy.


Sickle cell disease is inherited from parents in the same way as blood type, hair texture, eye color, and other physical characteristics are. The forms of hemoglobin produced in red blood cells are determined by the hemoglobin genes inherited from both parents. Individuals inherit one from each parent, as they do with most genes.


All of the children will have sickle cell trait if one parent has sickle cell anemia (SS) and the other has normal blood (AA). With each pregnancy, there is a 50% probability (1 chance out of 2) of having a baby with sickle cell illness or sickle cell trait if one parent has sickle cell anemia (SS) and the other parent has sickle cell trait (AS). Each pregnancy has a 25% probability (1 chance out of 4) of having a kid with sickle cell disease if both parents have sickle cell trait (AS).

How will I be able to tell if I have the Trait?

The type of hemoglobin will be determined by a simple, painless blood test followed by a laboratory method called Hemoglobin Electrophoresis. Varying hemoglobins move at different distances when an electric charge is passed through a hemoglobin solution, depending on their composition. This approach distinguishes between normal (A), sickle (S), and other hemoglobins (such as C, D, E, etc.).

Researchers didn't start looking into the ailment until 1952, when they determined that it was caused by a hemoglobin deficiency.

What are the signs and symptoms of sickle cell anemia, as well as its complications?

  1.   Periods of pain that can last little hours to a few days 
  2.   Blood clots
  3.   Swelling in hands and then feet
  4.   Joint pain that look like arthritis
  5.   Long-lasting neuropathic pain (nerve pain)
  6.   Severe infections
  7.   Anemia (reduction in red blood cells)

Is it able to differentiate between sickle cell anemia and sickle cell trait?


Yes. Without sickle cell disease, a person's red blood cells can include a mix of normal and defective hemoglobin. "Sickle cell trait" is the name for this condition. Sickle cell trait patients have enough normal hemoglobin in their red blood cells to keep them from sickling. Sickle cell trait affects one in every twelve African Americans in the United States.

It's crucial to understand that sickle cell trait does not mean you have sickle cell illness. Except in exceptional conditions, they rarely develop sickle cell disease. People with sickle cell trait, on the other hand, can transmit the trait down to their children genetically. If two persons with sickle cell trait have children together, their children have a one-in-four chance of developing sickle cell anemia.

Is sickle cell anemia curable?

No. There is currently no cure for sickle cell anemia. There are, however, medicines that have reduced the fatality rate among youngsters and the severity of the disease's agony.

Your healthcare professional will discuss what you can do to assist your child live a normal life if your newborn has sickle cell anemia. To avoid life-threatening infections, your baby may need to take medicine by mouth for up to ten years. Later in life, the focus of care shifts to pain management.

If I have sickle cell anemia, how can I control my pain?

During a vaso-occlusive crisis, acute discomfort might ensue (VOC). When sickle-shaped blood cells impede the flow of blood in small capillaries, this occurs. The VOC has the potential to cause tissue damage and suffering. This type of discomfort requires immediate medical attention.

Chronic pain, defined as pain that lasts longer than three to six months, affects some patients. It is unknown what causes chronic pain in some persons but not others. Chronic pain treatment should be targeted to the exact type of pain that is being experienced. Working with a pain management expert can assist you in managing your pain through a variety of approaches. The idea is to utilize the least quantity of medication possible while gaining the most function.






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