Women health

 How long does malaria stay in your system?


The effects of malaria infection on the body can be profound, resulting in long-term health effects ranging from increased susceptibility to bacterial infection to cognitive decline. Even though some of these negative consequences are well-known for the most serious types of disease, emerging evidence suggests that this is just the beginning.

According to specialists in the condition, immunity to the parasite develops with exposure to the illness, enabling apparently healthy people to regulate but not cure their sickness. Treatment is not sought because they no longer experience fever. The ensuing hidden, chronic infection not only adds to the spread of malaria but also gradually worsens people's health and ability to develop normally.

Acute organ failures, aberrant blood cell counts, and metabolic dysfunctions, both alone or in combination, are at the other extreme of the disease spectrum and cause severe malaria when infections are compounded by them. Even with the proper medications available, mortality remains high. Adding to the confusion, the WHO World Malaria Report for this year notes that it can be difficult to properly identify severe malaria cases, especially in places with few clinical and laboratory capabilities.

Malaria infection can cause severe neurological complications, the most serious of which is cerebral malaria. Sub-Saharan African children are the most afflicted, and those who survive frequently have lifelong conditions that can significantly lower their quality of life. These conditions include epilepsy, attention deficit hyperactivity disorder, and impairments of cognitive, and motor, including visual coordination.

An obvious clinical sign of cerebral malaria is a coma that advances quickly. Using age-specific coma scores with distinct cutoffs for kids and adults, this neurological condition is identified. At the moment, it is indicated by an adult Glasgow Coma Score of 11 or less (indicating a moderate to severe brain injury) and a kid Blantyre Coma Score of 3 or less.

Surprisingly, recent research in Ugandan children revealed that some of these long-term neurological consequences are also present in cases of cerebral malaria without a clinically diagnosed disease. The impact on the brain can occur regardless of the patient's level of consciousness, according to these unexpected new results. But since less research has been done on adults, there is far less information available.

This motivated our team to look into the occurrence of cerebral malaria-related brain alterations in patients who weren't in a coma. For malaria patients to receive better care and have better outcomes, it was essential to close this knowledge gap.s

Our current research, funded by the US National Institutes of Health and published in Clinical Infectious Diseases, makes the first-ever claim that unsuspected brain alterations are frequently brought on by malaria infections brought on by the Plasmodium falciparum parasite.

These results imply that a significant number of malaria patients may be suffering brain damage that goes unrecognized because they don't meet the diagnostic thresholds currently in place. This emphasizes the need for fresh approaches to finding cases with "silent" cerebral malaria and enhancing their paths for treatment.

We assessed the effects of P. falciparum infection on the brains of adult malaria patients in India who did not meet the diagnostic criteria for cerebral malaria using magnetic resonance imaging (MRI) scans of the individuals. These included individuals with simple malaria cases and people who had serious organ damage outside of the brain. We used a cutting-edge method to detect minute brain changes, and we were startled to find that both groups of infected people had varying degrees of brain damage.

Notwithstanding the absence of coma, the severe cases without obvious neurological consequences had a wide spectrum of brain alterations on MRI, with the most obvious findings resembling those we have previously seen in cerebral malaria. In addition, we discovered that compared to straightforward instances, this group exhibited increased plasma levels of S100B, a well-known marker of brain injury frequently linked to long-term cognitive problems.


They first question our current clinical definition of cerebral malaria because all adult patients with substantial MRI-detected brain abnormalities are not included in the Glasgow Coma Score cutoff of 11 or less.

From this perspective, it's significant to note that the WHO recently raised the threshold for adult cerebral malaria from 9 and below, where it had previously been placed. Despite this modification, a large number of adult patients who do not meet the stringent diagnosis nonetheless have cerebral involvement and may be at risk of developing post-infection neurological problems.

Although MRI scans are far more accurate at detecting cerebral damage caused by severe malaria, neuroimaging facilities are rarely accessible in regions where the disease is widespread, such as Africa or Southeast Asia. Therefore, new methods are required, such as biomarkers linked to potentially detrimental brain alterations seen on MRI, in order to quickly and accurately identify patients with silent cerebral malaria.

Additionally, and perhaps more crucially, it is unknown at this time whether these modifications will have short- or long-term consequences on neurological and cognitive processes following infection. The potential of modest but long-lasting problems, which have never been evaluated in this patient population, is strongly suggested by the combination of cerebral malaria-like MRI patterns and high plasma levels of a brain damage marker.

We urgently require investigations evaluating the magnitude and significance of brain alterations in adult patients with severe P. falciparum infection who are not in a coma in light of this new report in order to inform and create effective techniques to identify people at risk and aid in their recovery and rehabilitation.

Maintain good health while learning more!

Consider the advice we've given if you want to be as fit and healthy as you can be. By providing top-notch, fact-based services, we hope to enhance your general well-being. A group of subject-matter specialists has been assembled to produce training materials on various health-related subjects. To help you live the happiest life imaginable, we put much effort into educating you. Information on sound sleeping habits can be found in a section apart from the most recent news.


The article might receive a rating.


  1. Malaria symptoms
  2. Causes of malaria
  3. Malaria treatment
  4. Cerebral malaria
  5. Types of malaria and their symptoms


Post a Comment

Previous Post Next Post