Women health

 Does fasting reverse aging

According to recent studies, fasting activates a chemical that can prevent our arteries from getting older. The discoveries may aid in the prevention of age-related chronic illnesses like cancer, heart disease, and Alzheimer's.

An additional use for a chemical created while fasting has been found by researchers: it helps maintain the flexibility and youth of our circulatory system.

Since the time of Ancient Greece, the pursuit of eternal youth has captured people's attention.

Moreover, a short glance at Greek mythology reveals that youth was more highly desired than immortality, as certain myths depict the futility of the latter if it is not accompanied by the former.

Recently, contemporary medicine and classical mythology have begun to catch up in this area.

Recent technological developments give us reason to believe that the myth of eternal youth will soon come true.

In the latest study, scientists were able to prevent wrinkles and hair loss in mice. Another group of scientists was able to restore aging human cells.

A new study has now strengthened the case that aging can be stopped. Researchers under the direction of Dr. Ming-Hui Zou, director of the Center for Molecular & Translational Medicine at Georgia State University in Atlanta, demonstrated that fasting or calorie restriction can result in the production of a molecule that slows the aging process of the vascular system.

How a molecule called a ketone keeps cells young

According to Dr. Zou, the most significant aspect of aging is vascular aging. This is why she decided to conduct this study. Studying vascular aging is crucial because as humans age, the blood arteries supplying various organs become increasingly vulnerable and susceptible to aging-related damage.

Hence, the researchers decided to concentrate on vascular aging, senescence-related alterations, and methods of prevention.

The researchers focused on the relationship between calorie restriction and vascular aging. Dr. Zou conducted numerous cell culture studies and used atherosclerosis-prone mice models to examine the aortas of the dead animals. Similar tests were carried out on rodents that had been starved.

As they had predicted, they observed that the starved mice produced the chemical beta-hydroxybutyrate. But unexpectedly, this chemical also stopped the aging of the arteries.

A ketone is a substance created by the liver that serves as an energy source when glucose is not available. Beta-hydroxybutyrate is one such molecule. As a result of extended activity, low-carb diets, and fasting or famine, the body creates ketones.

A fascinating finding from the study was that beta-hydroxybutyrate encourages cell development and proliferation in the blood vessel lining. One indicator of cellular young is cellular division.

"We discovered that beta-hydroxybutyrate can postpone vascular aging. There is a chemical connection between calorie reduction, fasting, and the anti-aging effect.

Stopping chronic disease and aging with drugs

According to the study, the substance also starts a different series of events that preserves the integrity and youth of the endothelial cells' DNA.

Specifically, beta-hydroxybutyrate increases the activity of a stem cell transcriptional factor known as the Octamer-binding transcriptional factor when it binds to the RNA-binding protein heterogeneous nuclear ribonucleoprotein A1 (Oct4).

In response, Oct4 "increases Lamin B1, a critical factor against DNA damage-induced senescence," keeping the blood vessels young.

The stem cell factor Oct4 "may be a pharmaceutical or pharmacological target for slowing down or stopping aging.

Considering Alzheimer's disease, cancer, and cardiovascular disease are all age-related conditions, a younger vascular system will be less likely to develop any of them.

"Researchers think this is a really interesting finding, and we are focusing on discovering a new chemical that may duplicate the effect of this ketone body's activity," says Dr. Zou.

"It's hard to get people to stop eating for the next 24 hours to boost the concentration of this molecule, and not everyone can do that. But if we can develop something that can imitate this effect and people can still eat, it would make life more joyful and help battle disease."

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