Women health

Does type 1 diabetes cause liver problems?

According to the findings given at The Liver Meeting, patients with type 1 diabetes had a fourfold higher chance of developing chronic liver disease, including cirrhosis, than the general population.

Scientists in the United Kingdom used a computer database to identify 57 (1.2 percent) patients with type 1 diabetes who had undergone 82 liver biopsies from a longitudinal cohort of 4,644 people with the disease. Insulin-treated (n=57) and non-insulin-treated type 2 diabetic patients (n=57) were gender-matched. Both groups of people with type 2 diabetes had their livers biopsied.

301 liver biopsies were performed on 270 participants (2.8 percent) in the type 2 diabetes cohort (n=9,571). Type 1 diabetes patients had a lower rate of nonalcoholic fatty liver disease (OR=0.35; 95 percent CI, 0.15-0.82) than both type 2 diabetes groups, but they had a greater rate of glycogenosis diagnosis (OR=9.1; 95 percent CI, 1.10-75.75).

During the study's follow-up, 14 type 1 diabetes patients were diagnosed with cirrhosis, resulting in a prevalence of at least 301.5 (170-520) per 100,000 people, compared to a cirrhosis prevalence of 76.3/100,000 (OR=3.96; 95 percent CI, 2.24-7.01) in the general UK population. Type 1 diabetics had a lower cirrhosis diagnosis rate than type 2 diabetics who used insulin (OR=0.46; 95 percent CI, 0.23-0.91) and type 2 nonusers (OR=0.42; 95 percent CI, 0.21-0.84).

Twenty-two type 1 diabetes patients (38.6%) died throughout follow-up, resulting in a crude mortality rate of 6,539/100,000 person-years, compared to 1,878/100,000 person-years predicted by the National Diabetes Mortality Analysis 2007-08.

David J. Harman, PhD, hepatology research fellow at Nottingham Digestive Diseases Centre Biomedical Research Unit in England, told Healio.com, "A patient with type 1 diabetes is at a substantial risk of having liver disease, and I don't think it was something that was previously acknowledged." "To corroborate this findings and develop new algorithms to develop type 1 diabetes, prospective cohorts are required." But I believe this is the first step toward establishing that they, like their type 2 diabetes counterparts, are at high risk of liver damage."


Post a Comment

Previous Post Next Post